It was a period in which an epidemic of an ingenious virus occurred in Europe which affected scientists, explorers, inventors of many things including mathematics. Among these was Isaac Newton (1642-1727) who co-invented calculus, discovered the binomial theorem, and formulated a theory of universal gravitation (Smith). Newton was considered for almost 300 years the founding example of modern physical science, his results in experimental research were as innovative as those in mathematical research. Before discussing his three accomplishments, it is important to note that Newton had some college experience, but not his significant work was at home. Newton entered Trinity College, Cambridge, in 1661. His interest in mathematics began in the autumn of 1663, a date which corresponds to the beginning of his profound mathematical studies. When the plague forced the University to close in the summer of 1665, he returned to Lincolnshire [where he was born]. Over a period of less than two years, Newton began revolutionary advances in mathematics and other areas such as optics, physics, and astronomy (O'Connor and Robertson). It is important to know where most of his discoveries were made to understand the reasons behind his inventions. Newton is generally credited with the generalized binomial theorem which is valid for any exponent. When he began to read the works of Dr. Wallis, Newton was led to consider how to “interpolate the general values ​​of the areas of the second series…” (“The Life of Isaac Newton”). With this knowledge he investigated the arithmetic law of series coefficients and obtained a general method for interpolating other series. It later occurred to him that the same process of interpolating series... middle of paper... Works Cited "Isaac Newton" Bellevue College Inc. and Web. August 8, 2011. http://scidiv.bellevuecollege.edu/math /newton.htmlO'Connor, J.J. and Robertson, E.F. “Sir Isaac Newton.” Mac Tutor History of Mathematics, Inc. January 2000. Web. 31 August 2011. http://www-history.mcst-andrews.ac.uk/history/Printonly/Newton.html Smith, George, "Isaac Newton", The Stanford Encyclopedia of Philosophy (Fall 2008 edition), Edward N. Zalta (ed.), http://plato.stanford.edu/archives/fall2008/entries/newton/“The Life of Isaac Newton.” Library of the Third Millennium. Biohistory. nd Web. 31 August 2011. http://www.third-millennium-library.com/readinghall/GalleryofHistory/Life_of_Isaac_NewtonWilkins, D.R. “Sir Isaac Newton (1642-1727).” Trinity College Dublin School of Mathematics Inc. nd Web. 8 August 2011. http://www.maths.tcd.ie/pub/HistoryMath/People/Newton/RouseBall/RB_Newton.htm