Dehydration increases the viscosity of the blood, creating an environment in which red blood cells will have a greater tendency to stick together. As recommended by Brown (2012), intravenous (IV) fluids should be administered for rehydration while closely monitoring electrolytes and renal function to prevent under- or over-hydration. As demonstrated by the patient's condition, the nurse should encourage increased oral fluid intake (Brown, 2012). Hydrating the patient will reduce the viscosity of the blood and prevent the sickle red blood cells from clumping together and preventing proper circulation. Additionally, with improved circulation, tissues will receive adequate oxygen and nutrition, reversing tissue injury and reducing pain. Oxygen should also be administered to help increase the amount of circulating oxygen for individuals with an oxygen saturation less than 95% (Reddin, Cerrentano, & Tanabe,