Executive SummaryThis study illustrates the important roles and applications of bioinformatics, proteomics, and genomics in biotechnology. The study clearly describes that bioinformatics, proteomics and genomics play a significant role in drug discovery and design, agriculture, personalized drug development, biomarkers and many other areas which will be very useful in the present and also for future generations of living organisms. Finally, the study also highlights some points of recent bioinformatics, proteomics and genomics studies conducted by other researchers and their future capabilities are also clearly mentioned.1. IntroductionBiotechnology can be generally defined as the discipline that uses living organisms or their products for profit. It is not just an individual technology, but rather a combination of technologies that contribute to two general characteristics that work with living cells and their molecules and have a variety of practical uses that can improve our lives (Dunnill P., 1981).2. Definition of BioinformaticsBioinformatics is a discipline that is a mixture of molecular biology and computer science. In this field, computers are used to assemble, accumulate, analyze and incorporate biological and genetic information about living organisms. The need for bioinformatics emerged when the project to discover the sequence of the entire human genome was initiated (Chris S., 2003). This project was known as the “Human Genome Project”. This topic is considered very significant for using genetic information to learn about human diseases and to recognize new approaches when migration to normal recipient cells occurs. 5. Conclusion From the study it can be concluded that the methodologies involved in bioinformatics, proteomics and genomics have many applications in biotechnology and the techniques involved in these fields can be used to discover new drugs, understand the functions of cancer-causing genes, therefore to develop therapeutic drugs in the future and furthermore, the study found that with the improvement of technologies related to these fields many challenges such as developing a precise drug for prostate cancer and effective prediction of 3D protein structure can be addressed clearly. The information emerging from the study clearly describes that bioinformatics, proteomics and genomics have great potential today and in the future if adequately enhanced.